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Disease definition. Fetal hydantoin syndrome is a drug-related embryofetopathy that can occur when an embryo/fetus is exposed to the anticonvulsant drug. A clinical diagnosis of fetal hydantoin syndrome secondary to in utero phenytoin exposure was considered. Investigations showed vitamin D. This page includes the following topics and synonyms: Fetal Hydantoin Syndrome.

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Additional symptoms occurring with varying frequencies have been reported in the medical literature including congenital heart defects, cardiac rhythm disturbances, behavioral abnormalities such as attention deficit hyperactivity disorder, ocular defects including nearsightedness myopiajoint laxity, kidney abnormalities, and inguinal and umbilical hernia.

An umbilical hernia is when the intestines or fatty tissue pushes through the area near the bellybutton. Related links to external sites from Bing. Heart defects and cleft lip [3] may also be featured. This page was last edited on 17 Decemberat General Discussion Summary Fetal hydantoin syndrome is a characteristic pattern of mental and physical birth defects that results from maternal use of the anti-seizure anticonvulsant drug phenytoin Dilantin during pregnancy.

Fetal antiepileptic drug exposure: In addition, the potential role of other factors remains unclear, such as genetic influences that affect phenytoin metabolism or additional environmental factors e. Flat nasal bridge, ptosis of right upper eyelid, strabismus, and watery eyes Click here to view. How to cite this article: From Wikipedia, the free encyclopedia.

Distinctive facial features may be present including a flat, broad bridge of the nose; a short nose; eyes that are farther apart from each other than usual hypertelorism ; crossed eyes strabismus ; eyelids that droop ptosis ; a large, wide mouth; malformed ears; mild webbing of the neck pterygium colli ; and microcephaly. Surgical repair can be carried out in stages or in a single operation, according to the nature and severity of the defect. Other search option s Alphabetical list.

The neurological effects of phenytoin exposure in utero have not been clearly established by studies, which have demonstrated conflicting results.


Fetal hydantoin syndrome

Buehler BA, Finnell R. Feeding difficulties and frequent respiratory infections during infancy, diminished muscle tone hypotoniaabnormal looseness laxity of the joints, delayed bone age, developmental delays, hearing loss, and intellectual disability may also be present. Syndrme infants often develop similar symptoms regardless of the associated drug, particularly symptoms affecting the head and face region craniofacial abnormalities.

Cleft lip may be surgically corrected. Elsevier Saunders, Philadelphia, PA; Treatment is directed towards the symptoms that are present in an individual with CSS. NORD has a separate report called fetal valproate syndrome that discusses infants whose mothers took valproate during pregnancy. Basic Science and Clinical Practice. High arch palate Click here to view. Check this box if you wish to receive a copy of your message.

Am J Med Genet A. Fetal hydantoin syndrome may be caused by a combination of specific genetic and environmental factors. Int J Dev Neurosci.

Content is updated monthly with systematic literature reviews and conferences. Search Bing for all related images.

Prenatal prediction of risk of the fetal hydantoin syndrome. Health care resources for this disease Expert centres 95 Diagnostic tests 0 Patient organisations 9 Orphan drug s hydsntoin. Borderline to mild intellectual disability has been reported in some cases, and some studies have suggested that children exposed to phenytoin in the womb have a greater risk of developing learning disabilities, particularly in verbal skills.

Fetal Hydantoin Syndrome

Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years NEAD study: The exact incidence and prevalence of the disorder is unknown. A smaller population will have growth problems and developmental delayor intellectual disability. For information about clinical trials sponsored by private sources, contact: The concept of fetal antiepileptic syndromes in this regard is less useful than in the past and the broad consideration of the detal and minor congenital syndroome, various cognitive impairments, and behavioral abnormalities taken as a broader, collective concept is more appropriate.

Started inthis collection now contains interlinked topic pages divided into a tree of 31 shndrome books and chapters. Search other sites for ‘Fetal Hydantoin Syndrome’. Lateral profi le Click here to view. Coffin-Siris syndrome CSS is a rare genetic disorder that may be evident at birth congenital.

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There have been reports in the medical literature that women with mutations in the methylenetetrahydrofolate reductase MTHFR gene are at an increased risk of having an infant with fetal hydantoin syndrome. Foetal hydnatoin drug exposure and verbal versus non-verbal abilities at hydantoi years of age. As affected children grow older, the developmental delays improve, but studies suggest that children may remain slightly behind unexposed siblings.

Fetal hydantoin syndrome affects males and females in equal numbers. Treatment The treatment of fetal hydantoin syndrome is directed toward the specific symptoms that are apparent in each individual.

Radiograph of 85 Click here to view.

Fetal hydantoin syndrome is a characteristic pattern of mental and physical birth defects that results from maternal use of the anti-seizure anticonvulsant drug phenytoin Dilantin during pregnancy. Fetal alcohol syndrome FAS is a characteristic pattern of mental and physical birth defects that frtal due to maternal use of alcohol during pregnancy. These images are a random sampling from fetap Bing search on the term “Fetal Hydantoin Syndrome.

Prevention It is recommended that women be treated with a single anticonvulsant prior to conception and throughout pregnancy, since it appears that children exposed to multiple anticonvulsants may be at a greater risk for significant birth defects. Infobox medical condition new Articles to be expanded from March All articles to be expanded Articles with empty sections from March All articles with empty sections Articles using small message boxes.

Counseling is recommended for women to discuss the risks that syndfome prevent for both ssyndrome developing fetus and the expectant mother as well as the risks to the developing fetus involved with taking anti-seizure medications during pregnancy.

The specific symptoms and physical features associated with fetal hydantoin syndrome can vary greatly from one infant to another.