FETAL HYDANTOIN SYNDROME PDF
October 26, 2020 | by admin
Disease definition. Fetal hydantoin syndrome is a drug-related embryofetopathy that can occur when an embryo/fetus is exposed to the anticonvulsant drug. A clinical diagnosis of fetal hydantoin syndrome secondary to in utero phenytoin exposure was considered. Investigations showed vitamin D. This page includes the following topics and synonyms: Fetal Hydantoin Syndrome.
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Infobox medical condition new Articles to be expanded from March All articles to be expanded Articles with empty sections from March All articles with empty sections Articles using small message boxes. Int J Dev Neurosci. About one third of children whose mothers are taking this drug during pregnancy typically have intrauterine growth restriction with a small head and develop sndrome dysmorphic craniofacial features microcephaly and mentalretardation and limb defects including hypoplastic nails and distal phalanges birth defects.
Am J Med Genet A.
Front profi le Click here to view. Introduction Anti-seizure syndrone, also known as antiepileptic or anticonvulsant medications are among the most common teratogens prescribed to women of childbearing age. Symptoms may not be noticeable at birth congenitalbut will become apparent as an affected child grows older. The epidemiology of epilepsy in Rochester, Minnesota, through Some infants may have increased hair on the body and face.
Fetal Hydantoin Syndrome
Together we are strong. Congenital malformation due to exogenous toxicity Q86 Seizure Disorders in Pregnancy. Prenatal prediction of risk of the fetal hydantoin syndrome.
The specific symptoms and physical features associated with fetal hydantoin syndrome can vary greatly from one infant to another. Dilantin is the syndrime name of the drug phenytoin sodium in the United Hydatoin, commonly used in the treatment of epilepsy.
Cochrane Database Syst Rev. Symptoms of the following disorders can be similar to those of fetal hydantoin syndrome.
Additional symptoms occurring with varying frequencies have been reported in the medical literature including congenital heart defects, cardiac rhythm disturbances, behavioral abnormalities such as attention deficit hyperactivity disorder, ocular defects including nearsightedness myopiajoint laxity, kidney abnormalities, and inguinal and umbilical hernia. Investigational Therapies Information on current clinical trials is posted on the Internet at www.
You can help by adding to it. Standard Therapies Prevention It is recommended that women be treated with a single anticonvulsant prior to conception and throughout pregnancy, since it appears that children exposed to multiple anticonvulsants may be at a greater risk for significant birth defects. Case Rep Anesthesiol ; In addition, the potential role of other factors remains unclear, such as genetic influences that affect phenytoin metabolism or additional environmental factors e.
Treatment may require the coordinated efforts of a team of specialists. This page was last edited on 17 Decemberat Infants with fetal valproate syndrome are at a greater risk of developing neurological abnormalities than are infants whose mothers took other types of anti-seizure medications.
Researchers believe that the protein product of this gene plays a role in the proper breakdown metabolism of phenytoin or one of its metabolites. There have been reports in the medical literature that women with mutations in the methylenetetrahydrofolate reductase MTHFR gene are at an increased risk of having an infant with fetal hydantoin syndrome. Related Disorders Symptoms of the following disorders can be similar to those of fetal hydantoin syndrome.
Rare Disease Database
The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. Treatment is directed towards the symptoms that are present in an individual with CSS.
The concept of fetal antiepileptic syndromes in this regard is less useful than in the past and the broad consideration of the major and minor congenital malformations, various cognitive impairments, and behavioral abnormalities taken as a broader, collective concept is more appropriate.
Foetal antiepileptic drug exposure and verbal versus non-verbal abilities at three years of age.
Fetal hydantoin syndrome
Some current clinical trials also are posted on the following page on the NORD website: Maternal use of anti-seizure medications such as phenytoin, which is often used to treat epileptic seizures, can result in multiple effects on the developing embryo and fetus, including fetal hydantoin syndrome. Also, it is recommended that women taking phenytoin take folic acid supplements, both before conception and during pregnancy as a preventive measure against malformations.
Information on current clinical trials is posted on the Internet at www. NORD has a separate report on fetal valproate syndrome.